:root{--verde-sbr:#116C37;--verde-medio:#2E9E4F;--verde-claro:#7AC143;--azul:#1B7FA8;--laranja:#E8842A;--tinta:#28322C;--tinta-2:#5A6B60;--superficie:#fff;--superficie-2:#F2F6F3;--fundo:#F7FAF8;--borda:#DAE4DC;--critica:#B3261E;--estrutural:#B5641A;--moderada:#176E91;--inflamassoma:#116C37;--interferon:#B5641A;--nfkb:#1B6F92;--vasculopatia:#704188;--iatrogenia:#5A6B60;--transversal:#3E4E45;--shadow:0 12px 36px rgba(24,65,40,.09)}
*{box-sizing:border-box}html{scroll-behavior:smooth;scroll-padding-top:10rem}body{margin:0;background:var(--fundo);color:var(--tinta);font:400 1rem/1.65 Inter,ui-sans-serif,system-ui,-apple-system,BlinkMacSystemFont,"Segoe UI",sans-serif}a{color:var(--verde-sbr);text-decoration-thickness:.08em;text-underline-offset:.16em}a:hover{text-decoration-thickness:.13em}button,input,select{font:inherit}button,a{touch-action:manipulation}img{max-width:100%;height:auto}.container{width:min(1120px,calc(100% - 2rem));margin:auto}.skip{position:absolute;left:-999px}.skip:focus{left:1rem;top:1rem;z-index:999;background:#fff;padding:.75rem;color:#116C37}
.site-header{position:sticky;top:0;z-index:50;background:color-mix(in srgb,var(--superficie) 94%,transparent);border-bottom:1px solid var(--borda);backdrop-filter:blur(14px)}.topbar{min-height:68px;display:flex;align-items:center;gap:1rem}.brand{display:flex;align-items:center;gap:.7rem;color:var(--tinta);font-weight:800;text-decoration:none;min-width:0}.brand-disc{display:grid;place-items:center;width:40px;height:40px;border-radius:50%;background:var(--verde-sbr);color:white;font-size:1.1rem;flex:none}.brand-text{font-size:.95rem;line-height:1.15}.nav{display:flex;gap:.15rem;margin-left:auto}.nav a{min-height:44px;display:grid;place-items:center;padding:.45rem .7rem;text-decoration:none;color:var(--tinta-2);font-weight:650;font-size:.88rem;border-radius:8px}.nav-short{display:none}.nav a[aria-current=page],.nav a:hover{background:var(--superficie-2);color:var(--verde-sbr)}.header-tools{display:flex;align-items:center;gap:.35rem}.lang-switch{display:flex;border:1px solid var(--borda);border-radius:9px;overflow:hidden;background:var(--superficie)}.lang-switch a{min-width:34px;min-height:42px;display:grid;place-items:center;padding:.2rem;text-decoration:none;color:var(--tinta-2);font-size:.78rem;font-weight:800}.lang-switch a.active{background:var(--verde-sbr);color:#fff}.icon-btn{width:44px;height:44px;border:1px solid var(--borda);border-radius:9px;background:var(--superficie);color:var(--tinta);display:grid;place-items:center;cursor:pointer;font-weight:700}.header-seal{height:38px;width:auto;display:block;background:white;border-radius:6px}.mobile-menu{display:none}.searchbar{display:none;padding:0 0 .75rem}.searchbar.open{display:flex}.searchbar input{width:100%;min-height:46px;border:1px solid var(--borda);border-radius:9px;padding:.7rem 1rem;background:var(--superficie);color:var(--tinta)}
main{min-height:60vh}.hero{padding:3.5rem 0 2rem}.hero-grid{display:grid;grid-template-columns:1.3fr .7fr;gap:3rem;align-items:center}.eyebrow{font-size:.82rem;text-transform:uppercase;letter-spacing:.09em;font-weight:800;color:var(--verde-sbr);margin:0 0 .6rem}.hero h1,.page-head h1{font-size:clamp(2rem,5vw,3.5rem);line-height:1.04;letter-spacing:-.035em;margin:0;max-width:17ch}.hero h1.display-title{max-width:21ch;font-size:clamp(2.2rem,4.5vw,3.45rem);line-height:.98;text-wrap:balance}.display-title span{display:block}.display-title span:last-child{margin-top:.42rem;color:var(--verde-sbr);font-size:.66em;line-height:1.1;letter-spacing:-.015em}.hero-logo{background:#fff;border:1px solid var(--borda);border-radius:18px;padding:1rem;box-shadow:var(--shadow)}.thesis{font-size:1.1rem;max-width:69ch;margin:1.35rem 0;color:var(--tinta-2)}.author-card{border-left:4px solid var(--verde-sbr);padding:.2rem 0 .2rem 1rem;margin:1.5rem 0}.author-card strong{display:block}.author-card span{display:block;color:var(--tinta-2);font-size:.92rem}.door-grid,.card-grid,.disease-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:1rem}.door{background:var(--superficie);border:1px solid var(--borda);border-radius:12px;padding:1.25rem;text-decoration:none;color:var(--tinta);min-height:150px;display:flex;flex-direction:column;justify-content:space-between}.door:hover,.door:focus-visible{box-shadow:var(--shadow);border-color:var(--verde-sbr)}.door b{font-size:1.1rem}.door span:last-child{color:var(--verde-sbr);font-weight:800}.section{padding:2.5rem 0}.section.alt{background:var(--superficie-2);border-block:1px solid var(--borda)}h2{font-size:clamp(1.45rem,3vw,1.75rem);line-height:1.2;margin:0 0 1rem}h3{line-height:1.25}.muted{color:var(--tinta-2)}.page-head{padding:2.6rem 0 1.6rem}.page-head p{max-width:70ch;color:var(--tinta-2);font-size:1.05rem}
.figure-grid{display:grid;grid-template-columns:1fr 1fr;gap:1rem}.figure-card{margin:0;background:var(--superficie);border:1px solid var(--borda);border-radius:12px;padding:1rem}.figure-card button{width:100%;border:0;background:transparent;padding:0;cursor:zoom-in;text-align:left;color:inherit}.figure-card figcaption{font-size:.82rem;color:var(--tinta-2);margin-top:.85rem}.mechanism{display:grid;grid-template-columns:repeat(4,1fr);gap:.65rem}.mech-col{border:1px solid currentColor;border-radius:10px;padding:.85rem;background:var(--superficie)}.mech-col b{display:block}.mini-flow{font-size:.82rem;margin-top:.5rem}.organs{margin-top:.7rem;padding:.65rem;border-radius:8px;background:var(--superficie-2);text-align:center;font-weight:700}.venn{position:relative;min-height:300px;overflow:hidden}.venn-circle{position:absolute;width:190px;height:190px;border-radius:50%;display:grid;place-items:center;text-align:center;padding:2.2rem;color:#fff;font-weight:750;mix-blend-mode:multiply}.v1{background:rgba(17,108,55,.84);left:8%;top:20px}.v2{background:rgba(232,132,42,.84);right:8%;top:20px}.v3{background:rgba(27,127,168,.84);left:calc(50% - 95px);top:100px}.venn-center{position:absolute;z-index:3;left:50%;top:145px;transform:translate(-50%,-50%);font-size:.78rem;color:white;text-align:center;font-weight:800;width:100px}
.lecture-figure{display:block;width:100%;aspect-ratio:16/9;object-fit:contain;background:#fff;border-radius:8px}.lightbox .lecture-figure{width:min(100%,1600px);margin:auto}
.filters{background:var(--superficie);border:1px solid var(--borda);border-radius:12px;padding:1rem;margin-bottom:1rem}.filter-grid{display:grid;grid-template-columns:2fr repeat(4,1fr);gap:.65rem}.filters input,.filters select{width:100%;min-height:46px;border:1px solid var(--borda);border-radius:8px;background:var(--superficie);color:var(--tinta);padding:.55rem .7rem}.alphabet{position:sticky;top:68px;z-index:20;display:flex;gap:.2rem;overflow-x:auto;background:var(--fundo);padding:.6rem 0;margin-bottom:1rem}.alphabet a{flex:0 0 36px;height:36px;display:grid;place-items:center;border:1px solid var(--borda);background:var(--superficie);border-radius:50%;text-decoration:none;font-size:.82rem;font-weight:800}.result-count{font-size:.9rem;color:var(--tinta-2);margin:.6rem 0 1rem}.az-list{display:grid;grid-template-columns:repeat(3,1fr);gap:1rem}.comp-card{position:relative;background:var(--superficie);border:1px solid var(--path-color,var(--verde-sbr));border-radius:10px;padding:1rem;text-decoration:none;color:var(--tinta);display:grid;grid-template-columns:46px 1fr;gap:.8rem;min-height:160px}.comp-card>span:last-child,.detail-head>div{min-width:0}.comp-card:hover,.comp-card:focus-visible{box-shadow:var(--shadow);transform:translateY(-1px)}.letter-disc{width:46px;height:46px;border-radius:50%;background:var(--path-color,var(--verde-sbr));color:white;display:grid;place-items:center;font-size:1.25rem;font-weight:850}.comp-title{margin:0;font-size:1.04rem;overflow-wrap:break-word}.disease-name{display:block;font-style:italic;color:var(--tinta-2);font-size:.88rem;margin:.2rem 0;overflow-wrap:anywhere}.meta-row{display:flex;flex-wrap:wrap;align-items:center;gap:.4rem;margin-top:.65rem}.pill{border-radius:999px;color:#fff;padding:.16rem .52rem;font-size:.75rem;font-weight:800}.pill.critica{background:var(--critica)}.pill.estrutural{background:var(--estrutural)}.pill.moderada{background:var(--moderada)}.freq{font-size:.76rem;color:var(--tinta-2);font-weight:700}.featured{position:absolute;right:.75rem;top:.65rem;color:var(--verde-sbr);font-size:.75rem;font-weight:850;text-transform:uppercase;letter-spacing:.06em}.empty{grid-column:1/-1;text-align:center;padding:3rem;background:var(--superficie);border:1px dashed var(--borda);border-radius:12px}.reset{border:0;background:var(--verde-sbr);color:white;border-radius:8px;min-height:44px;padding:.5rem 1rem;font-weight:750;cursor:pointer}
.detail-head{display:grid;grid-template-columns:74px 1fr;gap:1rem;align-items:start}.detail-head .letter-disc{width:70px;height:70px;font-size:2rem}.detail-head h1{margin:.1rem 0;font-size:clamp(2rem,5vw,3rem);line-height:1.05}.detail-layout{display:grid;grid-template-columns:minmax(0,1fr) 260px;gap:2rem}.article{max-width:74ch}.article section{padding:1.2rem 0;border-bottom:1px solid var(--borda)}.article h2{font-size:1.35rem}.conduct{border:2px solid var(--verde-sbr)!important;border-radius:12px;padding:1.2rem!important;margin:1rem 0;background:color-mix(in srgb,var(--verde-sbr) 5%,var(--superficie))}.sidecard{position:sticky;top:140px;background:var(--superficie);border:1px solid var(--borda);border-radius:10px;padding:1rem;height:max-content}.path-link{font-weight:800;color:var(--path-color)}.prev-next{display:flex;justify-content:space-between;gap:1rem;padding:1.5rem 0}.prev-next a{max-width:48%}.deep-note{background:var(--superficie-2);border-radius:10px;padding:1rem;margin:.75rem 0}.timeline{display:grid;gap:.5rem}.timeline div{border-left:5px solid var(--verde-sbr);padding:.6rem .8rem;background:var(--superficie-2);border-radius:0 8px 8px 0}
.path-section{--path-color:var(--verde-sbr);background:var(--superficie);border:1px solid var(--path-color);border-radius:12px;padding:1.3rem;margin:1rem 0}.steps{display:grid;grid-template-columns:repeat(3,1fr);gap:.7rem}.step{background:var(--superficie-2);border-radius:8px;padding:.8rem}.trigger-list{display:grid;gap:.75rem}.trigger{background:var(--superficie);border:1px solid var(--borda);border-radius:10px;padding:1rem}.trigger b{display:block;color:var(--verde-sbr)}.disease-card{background:var(--superficie);border:1px solid var(--borda);border-radius:10px;padding:1rem}.disease-card h2{font-size:1.1rem;margin-bottom:.4rem}.facts{display:grid;gap:.35rem;font-size:.92rem}.facts strong{color:var(--verde-sbr)}.refs{display:grid;gap:.8rem}.ref{background:var(--superficie);border-left:4px solid var(--verde-sbr);padding:1rem}.ref a{overflow-wrap:anywhere}
.site-footer{margin-top:3rem;background:var(--superficie);border-top:1px solid var(--borda);padding:2rem 0}.logos{display:flex;gap:1.2rem;align-items:center;flex-wrap:wrap;padding:1rem;background:#fff;border-radius:10px}.logos img{max-height:48px;width:auto;object-fit:contain}.logos .wide{max-width:420px}.footer-grid{display:grid;grid-template-columns:1fr 1fr;gap:2rem;margin-top:1rem}.disclaimer{font-size:.82rem;color:var(--tinta-2)}.footer-author{font-size:.88rem}.footer-author strong,.footer-author span{display:block}.footer-author span{margin-top:.08rem}.lightbox{position:fixed;inset:0;z-index:100;background:rgba(0,0,0,.78);display:none;place-items:center;padding:1rem}.lightbox.open{display:grid}.lightbox-inner{max-width:1000px;width:100%;max-height:92vh;overflow:auto;background:var(--superficie);border-radius:12px;padding:1rem}.lightbox-close{float:right;min-width:44px;min-height:44px}.notice{background:#fff7ed;border:1px solid #fed7aa;color:#7c2d12;padding:1rem;border-radius:10px}.search-results{display:grid;gap:.45rem;margin-top:.6rem}.search-result{display:block;background:var(--superficie);border:1px solid var(--borda);border-radius:8px;padding:.65rem;text-decoration:none}
@media(max-width:1100px) and (min-width:901px){.brand-text{display:none}.nav a{padding-inline:.55rem}.header-seal{display:none}}
@media(max-width:900px){.nav a:nth-child(n+4){display:none}.hero-grid,.detail-layout{grid-template-columns:1fr}.hero-logo{max-width:560px}.az-list,.door-grid,.disease-grid{grid-template-columns:repeat(2,1fr)}.filter-grid{grid-template-columns:1fr 1fr}.sidecard{position:static}.mechanism{grid-template-columns:1fr 1fr}.footer-grid{grid-template-columns:1fr}}
@media(max-width:639px){.container{width:min(100% - 1.25rem,1120px)}.brand-text{display:none}.header-seal{display:none}.topbar{gap:.45rem}.header-tools{margin-left:auto}.lang-switch a{min-width:31px}.icon-btn{width:40px}.nav{position:fixed;left:0;right:0;bottom:0;display:grid;grid-template-columns:repeat(6,minmax(0,1fr));gap:0;background:var(--superficie);border-top:1px solid var(--borda);padding:.25rem .25rem max(.25rem,env(safe-area-inset-bottom));justify-content:stretch;z-index:80}.nav a,.nav a:nth-child(n){display:grid;font-size:.73rem;line-height:1.1;padding:.45rem .08rem;min-width:0;text-align:center}.nav-long{display:none}.nav-short{display:inline}.site-footer{padding-bottom:calc(5rem + env(safe-area-inset-bottom))}.hero{padding-top:2rem}.hero-grid,.az-list,.door-grid,.disease-grid,.figure-grid,.filter-grid,.mechanism,.steps{grid-template-columns:1fr}.hero h1.display-title{font-size:clamp(2rem,10vw,2.75rem);max-width:none;line-height:1.01}.display-title span:last-child{font-size:.7em}.hero-logo{width:100%}.alphabet{top:68px}.comp-card{min-height:145px}.footer-grid{gap:1rem}.logos{gap:.8rem}.logos img{max-width:100%;max-height:38px}.logos .wide{max-width:100%}.detail-head{grid-template-columns:58px minmax(0,1fr)}.detail-head .letter-disc{width:54px;height:54px;font-size:1.5rem}.detail-head h1{font-size:clamp(1.75rem,8.5vw,2rem);overflow-wrap:break-word}.figure-card{padding:.75rem}.venn-circle{width:155px;height:155px;padding:1.5rem;font-size:.78rem}.v1{left:0}.v2{right:0}.v3{left:calc(50% - 77px);top:110px}.venn-center{top:145px}.prev-next{font-size:.88rem}.footer-author,.disclaimer{font-size:.82rem}}
@media(max-width:359px){.container{width:min(100% - .85rem,1120px)}.topbar{gap:.25rem}.lang-switch a{min-width:29px}.icon-btn{width:38px}.nav a,.nav a:nth-child(n){font-size:.75rem;padding-inline:.08rem}.figure-card{padding:.55rem}}
@media(prefers-color-scheme:dark){:root:not([data-theme=light]){--tinta:#E8EFEA;--tinta-2:#B8C5BD;--superficie:#18201C;--superficie-2:#202A25;--fundo:#0F1512;--borda:#35443B;--shadow:0 12px 36px rgba(0,0,0,.25)}}
:root[data-theme=dark]{--tinta:#E8EFEA;--tinta-2:#B8C5BD;--superficie:#18201C;--superficie-2:#202A25;--fundo:#0F1512;--borda:#35443B;--shadow:0 12px 36px rgba(0,0,0,.25)}
@media(prefers-reduced-motion:reduce){*{scroll-behavior:auto!important;transition:none!important}}